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8 GIPR deficiency in mice leads to impaired glucose tolerance with reduced cell function, 9 while GIP overexpression results in improved glucose tolerance, enhanced cell function, and resistance to highfat dietinduced obesity

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These agents exert beneficial effects on myocardial contractility, vascular tone, endothelial integrity, and platelet aggregation, while also modulating inflammation, oxidative stress, and metabolic homeostasis at the cellular and molecular levels

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Abbreviations: 5 AMP, 5 adenosine monophosphate