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Authors' Contributions Zijun Ma, Kaiqin Jin, and Mengmeng Yue contributed equally to this work

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We followed the BCS approach as it provides a surrogate for in vivo bioequivalence studies

To enable the discovery of novel GLP-1R G-protein-biased agonists displaying selectivity and high potency for the GLP-1R, combinatorial peptide libraries were designed based on the competitive GLP-1R antagonist Ex 939 sequence to which 710 random amino acids have been added to the N terminus

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