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Indeed, acute activation of GIP signaling in hypothalamic cells results in a decreased food intake in rodents [40]

While there are no head-to-head trials specifically designed to compare tirzepatide plus metformin versus tirzepatide alone for weight loss, the available evidence suggests the combination is safe and effective, with metformin providing additional metabolic benefits without diminishing tirzepatide's weight loss effects

[18] [19] Patients should be instructed to report emergent suicidal thoughts or behaviors, and the medication should be discontinued if these occur

Hormonal differences in fat storage and mobilization also play a role

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