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Moreover, pharmacologic strategies such as metformin or GLP-1 receptor agonists are gaining interest not only for their metabolic benefits but also for their potential to improve mood and cognitive outcomes in patients with insulin resistance and treatment-resistant depression [62,69]

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The experimental drug puts semaglutide, the ingredient in Ozempic and the weight-loss drug Wegovy, together with a medicine called cagrilintide to make the combination Novo Nordisk calls CagriSema