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& Schoonjans, K

McGuire, found that oral semaglutide reduced major adverse cardiovascular events (MACE) to 3.1 events per 100 person-years, compared to 3.7 events in the placebo group a 14% reduction (HR 0.86) over a median follow-up of 49.5 months

GIP Receptor Distribution: **Adipose tissue: Adipocyte metabolism, nutrient partitioning Brain: Modulates energy balance Bone: May positively influence bone metabolism Clinically, this translates into greater weight loss than GLP-1 aloneoften approaching or exceeding 20% of body weight in trials

Even while reading about all these studies, one thing kept coming up again and again

Gut health affects mental health through several mechanisms

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