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To determine how GLP-1R activation alters calcium dynamics in VTA dopamine neurons during cocaine seeking, rats were pretreated with vehicle or exendin-4 (2.0 g/kg, i.p.) prior to a cocaine priming-induced reinstatement test session (Fig 6A)

These metabolic improvements not only support effective weight loss but also reduce long-term risks associated with diabetes, heart disease, and obesity-related complications

Obesity is one of the most common diseases worldwide

[See Adverse Reactions.] Therefore, a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia

GLP-1s were originally used as a treatment for type 2 diabetes

This tool helps identify duplicate GLP-1 therapy and inappropriate use through three targeted models: GLP-1 Concurrent Use : Flags members using multiple GLP-1 medications within a defined timeframe