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Athletes using these medications should work closely with sports medicine providers, consider body composition tracking beyond just weight, maintain high protein intake even with reduced appetite, prioritize resistance training, and monitor performance metrics to catch excessive muscle loss early

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If there are no side effects and that dose is effective, continue with that strength and dose

Despite widespread use, this population is underrepresented in clinical trials, creating a knowledge gap around long-term safety and optimal use

Prevention Perhaps you are already seeing the signs

Genetic variations in GLP-1 receptor (GLP1R), GIP receptor (GIPR), and appetite-regulation genes (FTO, MC4R) can predispose individuals to greater weight gain and reduced satiety signals