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DECLARATIONS Conflict of interest The authors declare no conflicts of interest

View product Retatrutide is a 39-amino-acid triple agonist that activates GLP-1, GIP and glucagon receptors simultaneously, modulating insulin secretion, glucagon suppression, and energy expenditure

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Recent clinical trials have demonstrated that semaglutide can significantly reduce body weight and visceral fat in women with PCOS, even in those who have not responded well to traditional lifestyle interventions or medications like metformin

While both medications are highly effective, tirzepatide acts on two hormone pathwaysGLP-1 and GIPallowing it to regulate appetite while also improving insulin sensitivity and fat metabolism

The theoretical basis for intranasal retatrutide delivery rests on several factors