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The effects of interventions combining vitamin D and calcium supplementation with or without physical activity, as well as the effects of bisphosphonates or other treatments in patients with osteoporosis and treated by GLP-1Ra, remain to be determined

Tirzepatide (Zepbound for obesity, Mounjaro for type 2 diabetes) is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

After being fed the HFD for 16 weeks, mice were treated every other day with either vehicle or triagonist (3 nmol/kg) for 3 weeks

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Further, observed improvements can be due to optimised formulations or excipients, rather than using a microneedle, which is not often disentangled in study designs

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