effective science-backed weight loss treatments with compounded semaglutide 💊 Thinking about starting a weight loss The Weight-Loss Drug Revolution—From Shots

Because tirzepatide produces more weight loss than semaglutide (dual receptor versus single receptor), and because orforglipron is a single GLP-1 receptor agonist, there was an expected gap in potency

See Exhibit 1 below

Plus, it comes in two flavors

STAR Protoc 2:100504 Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Patients should be counselled that regaining weight after stopping GLP-1 RAs can reverse improvements, potentially requiring medications to be resumed

Therefore, it remains unclear whether the impacts of GLP-1RAs and SGLT-2is on gut microbiota are additive, redundant, or interactive