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Hunter K, Hlscher C

The policy stems from budget constraints, not medical evidence

The SGLT2-I considered in the various RCTs include dapagliflozin ( n = 6 RCTs), empagliflozin ( n = 3 RCTs), ipragliflozin ( n = 2 RCTs), and canagliflozin ( n = 1 RCT), administered for a median period of 24 weeks

However, its usefulness for progressed DKD and established CVD remains unclear

Bolling stresses that the guidelines say the medications arent to be used alone and should be accompanied with lifestyle changes

Consistency matters more than precision Weight loss on tirzepatide is driven by sustained caloric deficit, which is driven by consistent appetite suppression, which is driven by steady drug levels