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Aghajani E, Nergaard BJ, Leifson BG, et al
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Denifanstat-treated patients also showed statistically significant fibrosis improvement by 1 stage with no worsening of NASH, and a greater proportion of MRI-derived proton density fat fraction (MRI-PDFF) 30% responders relative to placebo
Second, GLP-1RAs reduce neuroinflammatory changes in preclinical models
