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However, following a gradual dose escalation schedule, maintaining adequate B vitamin and mineral intake, optimizing sleep quality, managing stress, and monitoring for early sensory changes during dose increases may help reduce risk or enable early detection

None of these replace proper nutrition, but they fill gaps that the dietary transition might create

Some patients benefit from a slower titration schedule or temporarily pausing dose escalation if glycaemic targets are being met

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doi: 10.2337/db21-0848 Summary Keywords GLP-1 - glucagon-like peptide-1, GIP - glucose-dependent insulinotropic peptide, obesity, incretin, pharmacology Citation Douros JD, Flak JN and Knerr PJ (2025) The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP

This immunomodulation may facilitate the cardiovascular protection reported in outcome studies