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Analytic Approach National all-payer claims data were used to examine patient volumes for bariatric weight loss surgery, cardiac catheterization, GLP-1 medication use and SGLT2 inhibitor medication use from 2018 to 2023

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GLP1/E therapy also elicited specific changes in the hypothalamic proteomic profile in PNA mice, upregulating proteins involved in the metabolism of non-coding RNA, signaling of nuclear receptor and estrogen-dependent gene expression and downregulating pathways involved in apoptosis, signaling by insulin receptor and cellular responses to starvation

These new insights suggest that GLP-1R may be a potential target for the development of novel drugs in the treatment of OA

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