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At 12 months, patients receiving exenatide had a mean improvement of 2.7 points, while the control group had a mean decline of 2.2 points, indicating a statistically significant difference of 4.9 points (95% CI, 0.3-9.4

These results suggest that the gut microbiota, the gut microbiota-derived NMN, and the intestinal NAMPTNAD + SIRT axis collaborate to regulate intestinal homeostasis and systemic metabolic functions (Figure

Labs are not universally required at enrollment but may be triggered by the intake form

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The authors thank the Department of Health staff