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Blocking the catalytic breakdown of GLP-1 and GIP, allows for postprandial insulin release [44]

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This sounds revolutionary, but it has received a mixed reception among clinicians, with many citing concerns that once-monthly dosing may paradoxically worsen patient compliance (patients may simply forget to take the medication, as once-monthly administration may not be frequent enough to build adherence behaviours) and slow dose titration

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Since then, California, New Hampshire, and South Carolina stopped doing so, likely because of the drugs high costs and budget challenges, KFF said