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Acting on these receptors helps control appetite and reduce food intake, promoting significant weight loss

The reference lists from published articles and trials were manually retrieved and screened to identify relevant additional studies

These results have been more recently confirmed by the SUMMIT trial [63], showing that a once-weekly injection of tirzepatide (a dual glucose-dependent insulinotropic polypeptide receptor and GLP-1 RA) in obese patients with HfpEF induced a very similar reduction in the rate of worsening HF events compared to placebo (HR 0.59, 95% CI 0.410.82)

While this generally doesnt render other oral medications ineffective, it might delay their onset of action or alter their peak concentration

While these medications can help reduce overall body fat including belly fat by promoting weight loss, they do not specifically target the abdominal area
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