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In these studies, people also took a long-acting insulin to manage their blood sugar between meals and at night

General Clinical Approach: Most healthcare providers follow a stepwise approach to weight management pharmacotherapy: Monotherapy first : Optimize a single agent before considering combination therapy Lifestyle foundation : Ensure dietary modification and physical activity are maximized Adequate trial duration : Allow 3-6 months to assess full response to initial therapy Continuation criteria : Per guidelines, patients should achieve 5% weight loss after 12 weeks on a therapeutic dose to continue medication Reassess goals : Determine if additional intervention is truly necessary Given tirzepatide's superior efficacy compared to older weight loss medications, providers typically recommend optimizing tirzepatide dosing (up to 15 mg weekly for Zepbound) before adding other agents

Gastric emptying is more rapid in adolescents with type 1 diabetes and impacts on postprandial glycemia

Supplementary Material Contributor Information Kathrine Vauvert R Hviid, Department of Gynecology and Obstetrics, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

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