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GLP-1 receptor agonist use does not increase risk of respiratory complications post-endoscopy

Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014

- **Curb appetite:** Helping individuals feel full, potentially leading to reduced food intake

doi: 10.3389/fphar.2022.901559

985-P: Oral semaglutide as add-on to insulin in T2D: PIONEER 8

While it is tempting to use high and supraphysiological concentrations when testing a newly identified compound to ensure that an effect will be observed, from a microbiological standpoint, it would be more interesting to use concentrations that are physiologically representative of the in vivo situation in the gastrointestinal tract in order to unravel the mode of action of A
