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La molcula se construye sobre un esqueleto modificado del GIP nativo, al que se incorporan sustituciones de aminocidos no cannicos (aminoisobutrico, Aib) en posiciones 2 y 13 para conferir resistencia enzimtica frente a la dipeptidil-peptidasa-4 (DPP-4), y una cadena de cido graso C20 di-cido conjugada va un linker Glu-2xOEG en el residuo Lys20

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For the dataset of the tirzepatideGIPRG s Nb35 complex, automated particle selection yielded 4,260,187 particles, which were subjected to reference-free 2D classification, producing 1,771,599 particles with well-defined averages