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For readers looking at the bigger picture, gut health and longevity are often connected through long-term microbial diversity, barrier resilience, inflammatory balance, sleep consistency, and metabolic flexibility

In the context of MASLD/MASH, analogous rebound phenomena would be expected: regression of achieved steatosis resolution and potential re-emergence of inflammatory activity and fibrogenic stimuli upon drug withdrawal

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Therapeutic strategies targeting Caspase-3 cleavage of SPTBN1 or modulating nuclear translocation of SPTBN1 cleavage products could mitigate obesity-related metabolic dysregulation (Fig

Given the known sex-specific differences in placental function and fetal growth rate, it is also plausible that GLP-1RA effects on the placenta could vary by fetal sex

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