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Beyond its insulinotropic effects, GLP-1R signaling also influences lipid metabolism by modulating hepatic lipid handling and adipose tissue function

Key clinical trial comparisons They havent been pitted against each other in large-scale, direct head-to-head trials, but cross-trial analyses and meta-analyses give us a clear signal

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Akbulut U.E., Isik I.A., Atalay A., et al
TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice

Vildagliptin is capable of preserving the expression of this transporter in the membrane of pancreatic beta cells 27 , while Quercetin reduces glucose absorption by inhibiting GLUT2 in intestinal cells 28

But certainly in patients who may have a greater level of obesity associated with their type 2 diabetes, perhaps initiating semaglutide before an SGLT2 inhibitor because of the weight benefit, the CV risk lowering, as well as the CKD benefit, may be appropriate. More screening needed Providers are hopeful the FLOW trial may raise greater awareness of CKD screening, particularly the measurement of UACR