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Singh, S., Wright, E

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MC4R mutations are the most frequent cause of monogenic obesity in humans ( Estradiol also decreases appetite directly by increasing anorexigenic gene expression in POMC neurons and decreasing the expression of orexigenic genes in NPY/AgRP neurons (84, 86)

For glycaemic control in people with type 2 diabetes, doses of liraglutide above 1.8 mg once daily do not have a substantially greater effect

Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)