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The study showed significant decreases in HOMA2-B scores, proinsulin/insulin ratios, and proinsulin/C-peptide ratios in both tirzepatide (all doses) and dulaglutide compared to placebo [66]

Like other similar GLP-1 agonists, Mounjaro is approved to treat diabetes and is typically covered by most Medicaid plans for this purpose

Additional information This article is part of the Topical Collection on Therapeutic Trials Rights and permissions About this article Cite this article Goud, A., Zhong, J., Peters, M

Sources Efficacy and safety of GLP-1 for weight management: evidence from the STEP program Effect of continued weekly subcutaneous GLP-1 vs placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial GLP-1 for the treatment of overweight and obesity: a review Efficacy and safety of liraglutide and GLP-1 on weight loss in people with obesity or overweight: A systematic review

Weeks 1 Through 4: The Introduction Phase (2.5 mg) The first four weeks are all about letting your body adjust

Pricing Disclaimer: All pricing figures referenced in this article including Amazon Pharmacy cash-pay pricing, Direct Meds program pricing, and competitor pricing were based on publicly available information at the time of publication (April 2026) and are subject to change without notice