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In a diabetic kidney disease (DKD) model, liraglutide was demonstrated to enhance renal outcomes through the modulation of gut microbiota composition and the elevation of circulating levels of L-5-Oxoproline (5-OP)

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As part of the incretin system, GLP-1 helps stabilize post-meal glucose levels by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and increasing feelings of satiety (5)

It is extremely important not to rush the dose titration

If symptoms are limiting at a current dose, clinicians will often hold the dose steady or slow the schedule rather than push forward