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Tirzepatide and semaglutide have many of the same side effects, especially nausea, diarrhea, and appetite loss

This article was last reviewed for accuracy against available published evidence and UK regulatory guidance at the time of publication

Vomiting Vomiting is less common than nausea but can occur, particularly during the early weeks or after dose increases

However, Tirzepatide is a dual agonist that targets both the GLP-1 and glucagon receptors, while Semaglutide is a single GLP-1 receptor agonist

That said, brand and compounded are not regulatory equivalents

One represents pharmaceutical-grade stability testing backed by years of data