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There is, however, evidence to support considering closer follow-up when initiating a GLP-1 RA, particularly if rapid improvement in glycemic control is anticipated, following a baseline dilated fundus examination performed around the time of therapy initiation

Do Y, McKallip RJ, Nagarkatti M, Nagarkatti PS

Some researchers suggest that GLP-1 drugs may even reduce the activity of cells that produce collagen and elastin, which could further limit the skins ability to rebound

As the medication impacts glucose metabolism, it could also impact optic nerve health

Separately, there is a proposed class action lawsuit filed by a drug wholesaler alleging anticompetitive conduct by Novo Nordisk to delay generic Victoza entry into the market, seeking damages on behalf of purchasers rather than patients injured by the drug

However, these benefits are accompanied by concerns about side effects, cost, long-term sustainability and, above all, the loss of lean mass, which may be mitigated by concurrent exercise (1620)