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Rapid weight loss with GLP-1 medications can deflate deep and superficial facial fat compartments, exposing laxity and altering contours.

In animal models, GLP-1 agonists have been shown to significantly delay the onset and severity of experimental autoimmune encephalopathy symptoms, as well as to increase nerve myelination and brain weight

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For long-term adherence, and for the emotional and psychological relationship patients have with food, this distinction is enormously significant