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These results illustrate that Exe-9 enhanced the antitumor efficacy of anti-PD-1 in vivo, indicating a potential synergistic interaction between GLP-1R antagonism and immune checkpoint inhibition in suppressing colon cancer growth

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The proposed clinical trial endpoints are the resolution of steatohepatitis without worsening or liver fibrosis and/or improvement in liver fibrosis one stage or greater without worsening of steatohepatitis