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The FDAs decision was largely based on data from the SOUL trial, which included data from more than 9,000 patients who were randomized to oral Semaglutide or a placebo, & all patients had type 2 diabetes in addition to known ASCVD , CKD or both

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Retatrutide is studied in research settings because of its relationship with GLP-1, GIP and glucagon receptor pathways

California Cracks Down on GLP-1 Compounding New Rules Demand Stronger Clinical Justification California has tightened compounding rules, redefining essentially a copy and raising the bar for patient-specific documentation, especially for GLP-1 drugs like semaglutide and tirzepatide