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Older adults

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Modulate intercellular signaling pathways, such as Wnt/-catenin and Sonic Hedgehog, which regulate organ development and repair

BMI 30 kg/m2 (obese class I)
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Weight loss not only improves glycemic control but also reduces ectopic adipose tissue depots, such as perivascular and epicardial fat, that exert direct deleterious effects on the vascular endothelium [124]

doi: 10.1136/gut.44.1.81
