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doi: 10.3389/fphar.2014.00151 Received 27 May 2014 Accepted 10 June 2014 Published 01 July 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Richard Eugene Frye, Childrens Hospital Boston/Harvard Univerity, USA

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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)