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GIP has been shown to decrease food intake & increase energy expenditure, therefore resulting in weight reductions & when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose, & lipids

This temporal discrepancy may reflect differential mechanisms: early appetite suppression and reduced energy intake may drive initial weight reduction, whereas improvements in glycemic control may develop later through enhanced insulin sensitivity or central glucose regulation independent of weight loss

hazard ratio, 0.68 [95% CI, 0.461.00]

Understanding GLP-1 Medications and ADHD Drug Interactions GLP-1 receptor agonists (semaglutide and tirzepatide) work by slowing gastric emptying and signaling fullness in the brain, mechanisms distinct from how ADHD medications function

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