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It reversed glucose dysregulation without detrimental effects on metabolically healthy animals and reduced body weight, lowered fasting blood glucose, decreased glycosylated hemoglobin (HbA1C), improved glucose tolerance, and protected pancreatic islet architecture in diabetic fatty Zucker rats 14,19,20

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Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 randomized clinical trial

Six months in, I hit 142 pounds