eli lilly gip/glp-1 drmcgowan was just featured in USA Today as an expert voice on the biggest weight loss drug story of the year. 📰 Lilly's new drug retatrutide just posted the most significant ADA: Eli Lilly's next-gen GLP-1

Rossing P, Baeres FMM, Bakris G et al

But since then, the now 24-year-old is down to 144 pounds

Current GLP1 treatments are peptidebased injectables typically administered once weekly

Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus

Accordingly, and in line with currently ongoing trials in HFpEF (ClinicalTrials.gov IDs NCT04916470 and NCT04788511), it may be relevant to consider obesity-related HFpEF as a specific (sub)phenotype, whether coexisting with type 2 diabetes or not

General hydration guidance, not a GLP-1-specific rule, is the place to start, and your doctor can tailor it