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Those with isolated appetite control needs or who experience GIP-related GI side effects might respond better to semaglutide monotherapy

2.4 Immunomodulatory and anti-inflammatory effects GLP-1 receptor agonists have substantial immunomodulatory effects that beyond basic metabolic control

In April 2026, Canada approved a generic version of semaglutide see our Generic Ozempic Canada article for more details

Your BMI is 35 or higher and you have a weight-related health condition such as diabetes, high blood pressure, sleep apnea or fatty liver disease

The practical recommendation: if switching from brand-name Wegovy to compounded tirzepatide, use the same titration protocol (start 2.5 mg, escalate every 4 weeks)

Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced by enteroendocrine L-cells in the distal small intestine and colon in response to nutrient intake