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GLP-1 RAs could inhibit the expression of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) in human vascular endothelial cells in vitro, which had a protective effect against endothelial cell dysfunction (ECD) in the early stages of diabetic vascular disease [32] and might explain the lower incidence of background and severe nonproliferative DR among individuals who used GLP-1 RAs

10.1128/mbio.02032-23 mBio

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The gender distribution revealed that 57.5% of reports involved female patients, while male patients accounted for 40.5%, with the remaining 2.0% lacking gender specification