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After 4 weeks of 0.25 mg, increase dose to 0.5 mg once weekly

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If you are considering stopping the medication, say so

Berberine has been shown to improve glucose tolerance, 128 reduce body weight, 128 increase the expression of the insulin receptor (IR) and low-density lipoprotein (LDL) receptor, 129 lower total and LDL cholesterol levels, 129 and reduce triglyceride levels 128,129 in several rodent models

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There is an explanation of treatments and processes