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The biggest practical implication: tirzepatide can reduce the absorption of oral contraceptives by up to 59% for peak concentration.[6] Semaglutide doesnt do this to a clinically significant degree

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Sci Rep 6(1):26859 Zota I et al (2024) Stimulating Myelin restoration with BDNF: a promising therapeutic approach for Alzheimers disease

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These actions indirectly benefit the brain by minimizing the metabolic dysfunctions contributing to AD

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FDA's concerns with unapproved GLP-1 drugs used for weight loss

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Big difference

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These findings help to explain some aspects of TZPs clinical efficacy, but from this experiment, its impossible to discriminate whether the different effects of TZP are the result of GIPR signaling (85, 117, 118)

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