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While GLP-1s can be beneficial to the kidneys, there have been reported incidences of acute kidney failure (sudden)

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Figure 2 Dysfunction of GLP-1 and Diseases GLP-1 and AD AD is the most common neurodegenerative disease with an incurable cognitive impairment, but recently hope is proposed due to the development of Biogens monoclonal antibody drug aducanumab (ADU) in the USA

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World Obesity Atlas

Interestingly, liraglutide-treated Liv Fgf21/ mice displayed a sustained decrease in energy expenditure whereas this effect was attenuated in control mice