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6 Semaglutide produced significantly greater weight loss (an 1112 kg difference versus placebo) and larger improvements in pain (Western Ontario and McMaster Universities Arthritis Index [WOMAC] score: 41.7 versus 27.5)

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At the highest dose (3/6/9/12 mg escalation scheme), mean HbA1c was reduced by up to 1.6% and weight by nearly 9 kg, which was significantly greater than placebo

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