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Overview of efficacy, side effects, and key challenges GLP-1 receptor agonists such as semaglutide and liraglutide, as well as combination agents like tirzepatide (which adds glucose-dependent insulinotropic polypeptide receptor agonism)all hereafter referred to as GLP-1s for brevityare effective new agents for obesity treatment which demonstrate weight reduction, weight maintenance, and reduced morbidity and mortality

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While albiglutide demonstrated good glycemic efficacy and tolerability, adverse effects included upper respiratory tract infections, diarrhea, nausea, and injection site reactions

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Yang Y, Gao L

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These are the most frequently reported side effects and often improve after the first few weeks at each new dose

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Although glicentin was initially thought to comprise 100 amino acids, its purification from porcine intestine established glicentin as a 69-amino acid peptide [39]

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The greatest neuroprotective effects were seen by the use of DA4-JC and DA-CH5 which improve motor function, protect dopaminergic neurons, reduce inflammation, and rescue glial cell line-derived neurotrophic factor levels [114]

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