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Building on these reference trials, we specified two protocols that expanded eligibility to assess the effectiveness of semaglutide versus sitagliptin and tirzepatide versus dulaglutide in populations reflective of patients routinely seen in clinical practice, spanning low, moderate or high cardiovascular risk (Supplementary Table 26)

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The gradual dose increase strategy protects your body from overwhelming nausea or gastrointestinal side effects while maximizing weight loss potential

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Monitoring by a healthcare provider is recommended to ensure that dosages are optimized according to specific patient health requirements

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