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Other GLP-1 medications include liraglutide (Saxenda, Victoza), dulaglutide (Trulicity), and exenatide (Byetta, Bydureon)

Compared to GLP- 1 receptor mono-agonists and GLP- 1 receptor/GIP receptor co-agonists, optimized triagonists improve energy expenditure and restore body weight in DIO mice

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Landmark clinical trials, such as the STEP programme for semaglutide published in The New England Journal of Medicine, have demonstrated that these medications can lead to average weight loss of 15% or more when combined with lifestyle changes, a level of efficacy previously achievable only through bariatric surgery

Am J Med Sci 368:579588