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19% in placebo arm, p = 0.001), but no improvement in fibrosis (p = 0.24).25 There have also been subsequent safety concerns regarding the use of vitamin E, as data suggest a possible increased risk of overall mortality and higher rates of prostate cancer, though this remains controversial.[26], [27], [28] The insulin sensitiser pioglitazone, a thiazolidinedione, has been well studied and prescribed by some for the treatment of NASH, usually in line with diabetic practice guidelines

Without proper oversight, patientsespecially women in perimenopause or menopause can lose lean muscle , leading to long-term metabolic and health problems

Kang CH, Jung ES, Jung SJ, Han YH, Chae SW, Jeong DY, et al

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Dual incretins (tirzepatide) target both GLP-1 and GIP hormones for stronger appetite control