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Combining GIP and GLP-1R agonism was first discovered and reported a decade ago 40 and has now fully evolved as the GIP/GLP-1R co-agonist tirzepatide that can achieve more than 20% weight loss in obesity as well as offering superior benefits in diabetes

Source(s)of support Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2025MSXM106), the First batch of key Disciplines on Public Health in Chongqing, the National Natural Science Foundation of China (Grants 81501199 to C.W.), the Natural Science Foundation Project of Chongqing CSTC (cstc2017jcyjAX0016 to C.W

Endosomal escape: a bottleneck for LNP-mediated therapeutics

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