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While effective at achieving and maintaining weight loss, long-term use of incretin mimetics is likely needed to maintain weight since weight regain is common following drug discontinuation, with a return to baseline within a year 12,13

In much of the modern world, in which the population is now exposed to widely available and vastly excessive calories as well as to increasingly sedentary lifestyles 56,57,58,59 , these ancient survival-ensuring mechanisms are not merely irrelevant, but actually counter-productive and contribute to the obesity epidemic

It does not prove anything in isolation

26 , e13885 (2025)

Wegovy is the brand name for semaglutide specifically approved for chronic weight management

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