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They started low and slowly increased the dose over time

S2CID 2382791

It also lowers the risk of major cardiovascular (CV) events such as heart attack, stroke, or death in adults also with known heart disease

Gut Microbes , 18 (1), 2661854.

Retatrutide, also known as LY-3437943 or triple G is an investigational multi-agonist peptide studied for its activity at GLP-1, GIP and glucagon receptors