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Louis Aronne, a principal investigator on the clinical trial involving Zepbound and Wegovy, told ABC News that the success of drugs using tirzepatide is likely because the ingredient targets two hormones instead of one

Yue and colleagues showed that the GLP-1 agonist, liraglutide, reduced the transcriptional factor KLF2 and the rescued ox-LDL induced reduction of mitogen-activated protein kinase (MAPK) kinase extracellular signal regulated kinase 5 (ERK5) phosphorylation, and blockage of ERK5 activity on KLF2 expression [60]

At the same time, obesity is showing up more often across the world, and there is also more public awareness about obesity related health complications which, is pushing people toward better solutions

HIGHLIGHTS TriNetX cohort: adults with cirrhosis initiating GLP-1 after diagnosis

None of the providers can see the full treatment picture