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Overall, the benefit-risk profile supports broad use of GLP-1-based therapies in MASLD across most patient subgroups, with individualized monitoring plans for high-risk populations

Changing medical views on obesity The findings come as our understanding of obesitys impact on health evolves

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First discovered in distal intestinal peptide YY (PYY)-containing EECs 95 , neuropod cells in the intestine can sense sugars and transduce a signal to the brainstem within milliseconds via a single synapse 96

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After naltrexone is thoroughly discussed, patients should be given a naloxone challenge, with a dose of 0.4 mg IV, to assess the risk of precipitated withdrawal with naltrexone administration